More May Not Be Better — But Is Less Enough?

Oxygen – less is better , more is better ? ?

Altitude training has been employed as a tool for enhancing performance by athletes since the 1964 Mexico Olympics. The cost and impracticality of going to altitude regularly has led to the development of altitude simulation at sea level by creating low oxygen (‘hypoxia’) environments. ‘Altitude’ or ‘hypoxic’ training facilities are now springing up all around the country. The evidence supporti...

Metronomic Chemotherapy: When Less May Be More

The use of low dose continuous schedules of chemotherapy (i.e. metronomic chemotherapy), delivered at lower doses by necessity compared to traditional dosing schemes, has become an increasingly popular addition to patient management in veterinary medical oncology. While the concept itself is not new, as low dose, maintenance chemotherapy protocols have been important components of treatment for...

When Is More Not Better?

It is often assumed that when sensing in autonomous robot navigation, the more measurements taken, the better. In many cases, this is indeed true. However, we have found that in an outdoor, unstructured environment where the number of possible measurements one can take is limited and error is not normally distributed, additional measurements may cause more harm than good. These “rogue” measurem...

More palliative care specialists is not enough.

High-Dose Antiangiogenic Therapy for Glioblastoma: Less May Be More?

John F. de Groot Author’s Affiliations: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Running Title: Dosing effects of antiangiogenic therapy in glioblastoma